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Flea & Tick solutions for your dog & cat

Prevention solutions can protect your pet from fleas, ticks, lice and other harmful pests before they become a problem.

For a proactive approach to pest management, treat your pets monthly with flea and tick topical solutions, and spare them from the danger and discomfort of pesky bites and pest infestations.

PetSmart: your destination for value on top flea and tick brands.

K9 Advantix II

K9 Advantix® II*

(dogs only)

5-way topical treatment that kills and repels ticks, fleas, Mosquitoes, biting flies and lice. Kills all flea life stages.

K9 Advantix II - Learn more
Advantage II

Advantage® II

(dogs & cats)

Topical, all-stage flea & lice control in a once-monthly treatment.

Advantage II  - Learn more
FIPROGUARD™

SENTRY® FIPROGUARD™

(dogs & cats)

Fast-acting topical treatment that kills fleas, ticks & chewing lice.

FIPROGUARD™ - Learn more
Fiproguard-Max

SENTRY® FIPROGUARD™ MAX

(dogs & cats)

Fast-acting topical solution that starts killing fleas and ticks in as little as one hour.

Fiproguard Max - Learn more
FRONTLINE Plus

FRONTLINE® Plus

(dogs & cats)

#1 choice of veterinarians. Kills fleas and ticks within twelve hours of application.

FRONTLINE Plus - Learn more
Other Flea & Tick Products

Additional Products

Provide your pet instant relief with sprays and shampoos. Eliminate ticks and fleas from your home.

Other Flea & Tick - Learn more

* K9 Advantix® II is for use on dogs only.


Comparing "Spot-On" Topical Treatments

K9 Advantix® II*

Advantage® II

SENTRY® FIPROGUARD™

SENTRY® FIPROGUARD™ MAX

Kills Adult Fleas
Repels Fleas
Kills Flea Eggs & Larvae
Kills Ticks
Kills & Repels Mosquitoes
Other Parasite Info.Repels biting flies, kills liceKills lice on dogsKills liceKills lice, controls mites that may cause sarcoptic mange in dogs
Time to WorkWithin 12 hrsWithin 12 hrsWithin 12 hrs for fleas, 48 hrs for ticks1 hr
Waterproof
Active Ingredients(s)Imidacloprid,
Permethrin,
Pyriproxyfen
Imidacloprid,
Pyriproxyfen
FipronilFipronil, Cyphenothrin
When to ApplyMonthlyMonthlyMonthlyMonthly
Doses Available6 or 46 or 46 or 36 or 3
NotesFor use on dogs onlyGeneric equivalent to Frontline Top Spot. Kills fleas on contact, not through bite. Can be used on pregnant or nursing pets.

Comparing "Spot-On" Topical Treatments

FRONTLINE® Plus

SENTRY®

SENTRY® PRO XFT

Kills Adult Fleas
Repels Fleas
Kills Flea Eggs & Larvae
Kills TicksKills and detaches
Kills & Repels Mosquitoes
Other Parasite Info.Kills lice
Time to WorkWithin 12 hrs for fleas, 48 hrs for ticksKills over 92% of adult fleas and
ticks within 24 hrs
Within 1 hr for fleas, 3 hrs for ticks
Waterproof
Active Ingredients(s)Fipronil, (S)-
Methoprene
Permethrin, PyriproxyfenCyphenothrin, Pyriproxyfen
When to ApplyMonthlyMonthlyMonthly
Doses Available6 or 333
NotesSmall dog formula available