
For a proactive approach to pest management, treat your pets monthly with flea and tick topical solutions, and spare them from the danger and discomfort of pesky bites and pest infestations.
PetSmart: your destination for value on top flea and tick brands.
Fast-acting topical solution that starts killing fleas and ticks in as little as one hour.

#1 choice of veterinarians. Kills fleas and ticks within twelve hours of application.

Provide your pet instant relief with sprays and shampoos. Eliminate ticks and fleas from your home.

* K9 Advantix® II is for use on dogs only.
Comparing "Spot-On" Topical Treatments | K9 Advantix | Advantage | SENTRY® FIPROGUARD™ | SENTRY® FIPROGUARD™ MAX |
| Kills Adult Fleas | ![]() | ![]() | ![]() | ![]() |
| Repels Fleas | ![]() | |||
| Kills Flea Eggs & Larvae | ![]() | ![]() | ||
| Kills Ticks | ![]() | ![]() | ![]() |
|
| Kills & Repels Mosquitoes | ![]() | |||
| Other Parasite Info. | Repels biting flies, kills lice | Kills lice on dogs | Kills lice | Kills lice, controls mites that may cause sarcoptic mange in dogs |
| Time to Work | Within 12 hrs | Within 12 hrs | Within 12 hrs for fleas, 48 hrs for ticks | 1 hr |
| Waterproof | ![]() | ![]() | ![]() | ![]() |
| Active Ingredients(s) | Imidacloprid, Permethrin, Pyriproxyfen | Imidacloprid, Pyriproxyfen | Fipronil | Fipronil, Cyphenothrin |
| When to Apply | Monthly | Monthly | Monthly | Monthly |
| Doses Available | 6 or 4 | 6 or 4 | 6 or 3 | 6 or 3 |
| Notes | For use on dogs only | Generic equivalent to Frontline Top Spot. Kills fleas on contact, not through bite. Can be used on pregnant or nursing pets. |
Comparing "Spot-On" Topical Treatments | FRONTLINE | SENTRY® | SENTRY® PRO XFT |
| Kills Adult Fleas | ![]() | ![]() | ![]() |
| Repels Fleas | ![]() | ![]() |
|
| Kills Flea Eggs & Larvae | ![]() | ![]() | ![]() |
| Kills Ticks | ![]() | ![]() | Kills and detaches |
| Kills & Repels Mosquitoes | ![]() | ![]() |
|
| Other Parasite Info. | Kills lice | ||
| Time to Work | Within 12 hrs for fleas, 48 hrs for ticks | Kills over 92% of adult fleas and ticks within 24 hrs | Within 1 hr for fleas, 3 hrs for ticks |
| Waterproof | ![]() | ||
| Active Ingredients(s) | Fipronil, (S)- Methoprene | Permethrin, Pyriproxyfen | Cyphenothrin, Pyriproxyfen |
| When to Apply | Monthly | Monthly | Monthly |
| Doses Available | 6 or 3 | 3 | 3 |
| Notes | Small dog formula available |